Palmar papules as a manifestation of cutaneous oxalosis in primary hyperoxaluria: A case report and review of the literature
Year: 2024
Type: article
Study design: Case Report
Abstract: Introduction:The term ”oxalosis” refers to the systemic buildup of calcium oxalate, the insoluble salt of oxalic acid, outside of the urinary system. Primary and secondary hyperoxalurias are the pathologic disease processes in charge of causing systemic oxalosis. The kidneys, bone, heart, blood arteries, and skin are major sites of oxalate accumulation that result in illness1. The primary hyperoxalurias are a class of uncommon autosomal recessive metabolic diseases characterised by abnormally excessive generation of serum oxalate and consequent tissue deposition. Most individuals first exhibit recurrent urolithiasis and renal failure when they are young. Primary hyperoxalurias are characterised by vascular deposition of skin manifestations that produce oxalate, such as livedo reticularis, acrocyanosis, peripheral gangrene, and ulcerations2. Skin symptoms, on the other hand, are uncommon in individuals who develop an oxalosis caused by renal insufficiency and, when they do, they are the consequence of extravascular deposition, resulting in calcified nodules and miliary papules3. Globally, it is estimated that 1 in 58,000 people suffer with primary hyperoxaluria. With Type 1 accounting for around 80% of cases, it is the most prevalent kind. Each of the two types accounts for around 10% of cases4. here we report a case of a 23 year-old female patient with a cutaneous oxalosis without livedo reticularis, acrocyanosis and ulceration, and it could be a very rare case in medical literature.
Source: Clinical Case Reports
DOI: 10.1002/ccr3.8423
Authors: Hadi Alabdullah, Jameel Soqia, Thaer Douri
Institutions: Hama University, Damascus University
Language: English
Subfield: Urology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,730
OpenAlex ID: W4390598568