Protocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of In Vitro Studies
Year: 2023
Type: article
Study design: Study Protocol
Abstract: A tool for evaluation of internal validity of in vitro studies called INVITES-IN is currently under development. The tool is designed specifically for cell culture studies.This protocol describes the testing of the performance of INVITES-IN. By performance, we mean the extent to which results of using INVITES-IN are the same for different users (consistency), the amount of time and cognitive effort it takes to apply INVITES-IN (assessor workload), the precision and potential for systematic error in results of applying INVITES-IN (accuracy), and how easy it is to use INVITES-IN (user experience).The participants in the user testing will be representative for the expected end-users of INVITES-IN which are persons preparing literature reviews including in vitro studies (e.g. in the context of chemical hazard and risk assessments or drug development). All end-users are expected to have experience with in vitro methods.Data collected from the performance testing will be used for further refinement and development of the release version of INVITES-IN.
Source: Evidence-Based Toxicology
Authors: Gro H. Mathisen, Gunn E. Vist, Paul Whaley, Richard A. White, Trine Husøy, Heather M. Ames, Anna Beronius, Emma Di Consiglio, Ingrid Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Pilar Prieto, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Camilla Svendsen
Institutions: Norwegian Institute of Public Health, Lancaster University, Karolinska Institutet, Istituto Superiore di Sanità, Environmental Protection Agency, Johns Hopkins University, University of Konstanz, Radboud University Medical Center, Benaki Phytopathological Institute, Joint Research Centre, University of California, San Francisco, National Institute of Environmental Health Sciences, University of Basel, Swiss Centre for Applied Human Toxicology, Vrije Universiteit Brussel
Language: English
Subfield: Statistics, Probability and Uncertainty
Field: Decision Sciences
Domain: Social Sciences
Open Access status: diamond
OpenAlex ID: W4390617697