Extracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors
Year: 2024
Type: article
Study design: Observational Study
Abstract: The Extracorporeal Life Support Organization (ELSO) maintains the world's largest extracorporeal membrane oxygenation (ECMO) registry by volume, center participation, and international scope. This 2022 ELSO Registry Report describes the program characteristics of ECMO centers, processes of ECMO care, and reported outcomes. Neonates (0-28 days), children (29 days-17 years), and adults (≥18 years) supported with ECMO from 2009 through 2022 and reported to the ELSO Registry were included. This report describes adjunctive therapies, support modes, treatments, complications, and survival outcomes. Data are presented descriptively as counts and percent or median and interquartile range (IQR) by year, group, or level. Missing values were excluded before calculating descriptive statistics. Complications are reported per 1,000 ECMO hours. From 2009 to 2022, 154,568 ECMO runs were entered into the ELSO Registry. Seven hundred and eighty centers submitted data during this time (557 in 2022). Since 2009, the median annual number of adult ECMO runs per center per year increased from 4 to 15, whereas for pediatric and neonatal runs, the rate decreased from 12 to 7. Over 50% of patients were transferred to the reporting ECMO center; 20% of these patients were transported with ECMO. The use of prone positioning before respiratory ECMO increased from 15% (2019) to 44% (2021) for adults during the coronavirus disease-2019 (COVID-19) pandemic. Survival to hospital discharge was greatest at 68.5% for neonatal respiratory support and lowest at 29.5% for ECPR delivered to adults. By 2022, the Registry had enrolled its 200,000th ECMO patient and 100,000th patient discharged alive. Since its inception, the ELSO Registry has helped centers measure and compare outcomes across its member centers and strategies of care. Continued growth and development of the Registry will aim to bolster its utility to patients and centers.
Source: ASAIO Journal
Authors: Joseph E. Tonna, Philip S. Boonstra, Graeme MacLaren, Matthew Paden, Daniel Brodie, Marc Anders, Aparna Hoskote, Kollengode Ramanathan, Rob Hyslop, Jeffrey J. Fanning, Peter Rycus, Christine Stead, Nicholas A. Barrett, Thomas Mueller, Rene D. Gómez, Poonam Malhotra Kapoor, John F. Fraser, Robert H. Bartlett, Peta M.A. Alexander, Ryan P. Barbaro
Institutions: University of Utah, University of Utah Health Care, University of Michigan, National University Hospital, Emory University, Johns Hopkins University, Johns Hopkins Medicine, Baylor College of Medicine, Texas Children's Hospital, Great Ormond Street Hospital, Great Ormond Street Hospital for Children NHS Foundation Trust, University College London, National University of Singapore, National University Heart Centre Singapore, National University Health System, Children's Hospital Colorado, Medical City Children's Hospital, Extracorporeal Life Support Organization, King's College London, Guy's and St Thomas' NHS Foundation Trust, University Hospital Regensburg, Tecnológico de Monterrey, All India Institute of Medical Sciences, The University of Queensland, Prince Charles Hospital, Boston Children's Hospital, Harvard University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: LivaNova, Extracorporeal Life Support Organization, Abiomed, Xenios, National Institutes of Health, U.S. Food and Drug Administration, University of California, San Francisco, National Heart, Lung, and Blood Institute, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Pediatric ECMO Anticoagulation Collaborative (PEACE) Consensus, University of Utah Center for Clinical and Translational Science, Optimizing Selection and Management of Cardiac Arrest Patients Treated with ECMO, ASCEND (ARDS in Children and ECMO initiation strategies impact on Neuro-Development), G3897007235, University of Utah Center for Clinical and Translational Science-UL1, Utah Center for Clinical and Translational Science, G6490171314, G6610709059, G7108608281, University of Utah Center for Clinical and Translational Science-UL1
OpenAlex ID: W4390629178