Work

New pyrazolo[3,4- d ]pyrimidine derivatives as EGFR-TK inhibitors: design, green synthesis, potential anti-proliferative activity and P-glycoprotein inhibition

Year: 2024

Type: article

Abstract: = 0.267 and 0.844 μM, respectively. Additionally, compound 16 was found to induce cell cycle arrest at the S phase with a subsequent increase in pre-G cell population in MDA-MB-468 cell line. It also increased the percentage of apoptotic cells in a time-dependent manner. Moreover, a molecular docking study was carried out to explain the target compounds' potent inhibitory activity within the EGFR binding site.

Source: RSC Advances

DOI: 10.1039/d3ra05401b

Authors: Aya I. Hassaballah, Asmaa M. AboulMagd, Magdy M. Hemdan, Mohamed H. Hekal, Amira A. El-Sayed, Paula S. Farag

Institutions: Ain Shams University, Nahda University

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042