Copper (II) complexes with (E)-N′(3,5-di-tert-butyl-2-hydroxybenzilidene)-2-hydroxybenzohydrazide, their bactericidal and fungicidal activity
Year: 2024
Type: article
Abstract: Annotation A mononuclear complex of copper(II) with (E)-N′(3,5-di-tert-butyl-2-hydroxybenzilidene) -2-hydroxybenzohydrazide (H3sahz)2 was synthesized. The structure of the complex [Cu(H2sahz)(DMF)] was studied by elemental analysis, IR and EPR spectroscopy, and monocrystal X-ray analysis. It was shown that the complex has a square planar structure, in which the ligand is tridentate and dianionic. The coordination of the Cu(II) ion is carried out by the oxygen atom of the ditertbutyl fragment, the azomethine nitrogen atom, the hydrazide oxygen atom in the enol form, and the oxygen of the DMF molecule. In aqueous solutions, the DMF molecule in the complex is easily exchanged for a water molecule. The obtained ligand and complex possess high bactericidal and fungicidal activity. The results of these studies indicated that the metal complexes exhibit a stronger antibacterial and antifungal efficiency than their corresponding Schiff base ligands.
Source: Transition Metal Chemistry
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4390948643