Year: 2024
Type: review
Abstract: Tumor-associated macrophages (TAMs) are the major component of the tumor microenvironment (TME), where they sustain tumor progression and or-tumor immunity. Due to their plasticity, macrophages can exhibit anti- or pro-tumor functions through the expression of different gene sets leading to distinct macrophage phenotypes: M1-like or pro-inflammatory and M2-like or anti-inflammatory. NF-κB transcription factors are central regulators of TAMs in cancers, where they often drive macrophage polarization toward an M2-like phenotype. Therefore, the NF-κB pathway is an attractive therapeutic target for cancer immunotherapy in a wide range of human tumors. Hence, targeting NF-κB pathway in the myeloid compartment is a potential clinical strategy to overcome microenvironment-induced immunosuppression and increase anti-tumor immunity. In this review, we discuss the role of NF-κB as a key driver of macrophage functions in tumors as well as the principal strategies to overcome tumor immunosuppression by targeting the NF-κB pathway.
Source: Genes
Institutions: Imperial College London, University of L'Aquila
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,955
Awards: G1029897587, G1662065590, Imperial College London – Confidence in Concept 2019, G2083859247, G2117545861, G2445949685, G2600449259, G3298275574, G3534681832, G4108308124, Treating Multiple Myeloma and Diffuse Large B Cell Lymphoma by Targeting the NF-kB Pathway with the First-in-Class GADD45b/MKK7 Inhibitor, DTP3, G5046496225, G5278655962, G5473302966, G5796929153, G6417102507, G6420839184, G6808865990, G7097851743, G7178552386, G7508784161, G7548786943, G8950771732
OpenAlex ID: W4391403444