Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation
Year: 2024
Type: article
Study design: Observational Study
Abstract: Epstein-Barr virus (EBV) and human leukocyte antigen (HLA) polymorphisms are well-known risk factors for nasopharyngeal carcinoma (NPC). However, the combined effects between HLA and EBV on the risk of NPC are unknown. We applied a causal inference framework to disentangle interaction and mediation effects between two host HLA SNPs, rs2860580 and rs2894207, and EBV variant 163364 with a population-based case-control study in NPC-endemic southern China. We discovered the strong interaction effects between the high-risk EBV subtype and both HLA SNPs on NPC risk (rs2860580, relative excess risk due to interaction [RERI] = 4.08, 95% confidence interval [CI] = 2.03-6.14; rs2894207, RERI = 3.37, 95% CI = 1.59-5.15), accounting for the majority of genetic risk effects. These results indicate that HLA genes and the high-risk EBV have joint effects on NPC risk. Prevention strategies targeting the high-risk EBV subtype would largely reduce NPC risk associated with EBV and host genetic susceptibility.
Source: Cell Genomics
Authors: Miao Xu, Ruimei Feng, Zhonghua Liu, Xiang Zhou, Yanhong Chen, Yulu Cao, Linda Valeri, Zilin Li, Zhiwei Liu, Su-Mei Cao, Qing Liu, Shang-Hang Xie, Ellen T. Chang, Wei-Hua Jia, Jincheng Shen, Youyuan Yao, Yong-Lin Cai, Yuming Zheng, Zhe Zhang, Guangwu Huang, Ingemar Ernberg, Minzhong Tang, Weimin Ye, Hans-Olov Adami, Yi-Xin Zeng, Xihong Lin
Institutions: Harvard University, Sun Yat-sen University, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Shanxi Medical University, Division of Cancer Epidemiology and Genetics, Columbia University, Guangzhou Women and Children Medical Center, Guangzhou Medical University, Northeast Normal University, University of California, San Francisco, University of Utah, Jiangsu Province Hospital, Nanjing Medical University, Wuzhou Red Cross Hospital, First Affiliated Hospital of GuangXi Medical University, Karolinska Institutet, Fujian Medical University, University of Oslo
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $8,900
OpenAlex ID: W4391493418