Work

1,7-Hydride transfer-involved dearomatization of quinolines to access C3-spiro hydroquinolines

Year: 2024

Type: article

Abstract: 1,7-Hydride transfer-involved dearomatization of quinolines toward C3-spiro hydroquinoline derivatives has been developed. This method offers a protocol to achieve the dearomatization of electron-deficient arenes via the redox-neutral hydride transfer process. A series of C3-spiro hydroquinolines can be provided in moderate to excellent yields (up to 98%) with good diastereoselectivities. Significant advantages such as high step- and atom-economy, as well as redox-neutral and mild conditions, make it an appealing alternative to achieve the dearomatization of quinolines.

Source: Green Synthesis and Catalysis

DOI: 10.1016/j.gresc.2024.01.008

Authors: Da-Ying Shao, Bin Qiu, Zi-Kang Wang, Zhen-Yuan Liu, Jian Xiao, Xiao-De An

Institution: Qingdao Agricultural University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Natural Science Foundation of China, Natural Science Foundation of Shandong Province

Awards: G1821795519, G2144468772, G5426673035, G993419089