Work

Excitotoxicity and ALS: New therapy targets an old mechanism

Year: 2024

Type: article

Abstract: Excitotoxicity-induced cell death in motor neurons is a major therapeutic target for amyotrophic lateral sclerosis (ALS). Yan et al. 1 present a novel compound to specifically disrupt extra-synaptic NMDAR complexes, extending the lifespan of the SOD1 G93A ALS mouse and ameliorating cell death. Excitotoxicity-induced cell death in motor neurons is a major therapeutic target for amyotrophic lateral sclerosis (ALS). Yan et al. present a novel compound to specifically disrupt extra-synaptic NMDAR complexes, extending the lifespan of the SOD1 G93A ALS mouse and ameliorating cell death.

Source: Cell Reports Medicine

DOI: 10.1016/j.xcrm.2024.101423

Authors: Hannah Louise Smith, Helena Chaytow, Thomas Henry Gillingwater

Institutions: Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,460