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Abdominal attack in a patient with hereditary angioedema due to C1 inhibitor deficiency complicated by a perforated peptic ulcer

Year: 2024

Type: article

Abstract: A 30-year-old male with hereditary angioedema (HAE) due to C1 inhibitor deficiency was admitted to the Emergency Department (ED) due to severe abdominal pain lasting for 3 hs with severe bloating and weakness.pdC1INH and fluids were applied as usual and the patient was discharged with feeling better.A few hours later abdominal symptoms recurred and erythema appeared, thus the allergy to antispasmodic drug taken by the patient was suspected.In the ED, the patient received anti-allergic treatment and was discharged again.After 3 h severe abdominal symptoms returned with fever.The patient was readmitted to the ED with peritoneal symptoms.Abdominal X-ray confirmed digestive tract perforation.Laparotomy revealed perforation of the chronic duodenal ulcer.In conclusion, we indicate that a HAE patient with an abdominal pain not resolving after usually effective treatment, should be hospitalized and monitored.Differential diagnosis of reasons other than HAE attack should be made.

Source: Alergologia Polska - Polish Journal of Allergology

DOI: 10.5114/pja.2024.135548

Authors: Piotr Obtulowicz, Marcin Stobiecki, Wojciech Dyga, Tadeusz Popiela, Krystyna Obtulowicz

Institutions: Szpital Uniwersytecki w Krakowie, Jagiellonian University

Language: English

Topic: Coagulation, Bradykinin, Polyphosphates, and Angioedema

Subfield: Genetics (clinical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4391980985