Year: 2024
Type: review
Abstract: Post-intensive care syndrome comprises physical, cognitive, and mental impairments in patients treated in an intensive care unit (ICU). It occurs either during the ICU stay or following ICU discharge and is related to the patients' long-term prognosis. The same concept also applies to pediatric patients, and it can greatly affect the mental status of family members. In the 10 years since post-intensive care syndrome was first proposed, research has greatly expanded. Here, we summarize the recent evidence on post-intensive care syndrome regarding its pathophysiology, epidemiology, assessment, risk factors, prevention, and treatments. We highlight new topics, future directions, and strategies to overcome post-intensive care syndrome among people treated in an ICU. Clinical and basic research are still needed to elucidate the mechanistic insights and to discover therapeutic targets and new interventions for post-intensive care syndrome.
Source: Acute Medicine & Surgery
DOI: 10.1002/ams2.929
Authors: Shigeaki Inoue, Nobuto Nakanishi, Fumimasa Amaya, Yoshihisa Fujinami, Junji Hatakeyama, Toru Hifumi, Yuki Iida, Daisuke Kawakami, Yusuke Kawai, Yutaka Kondo, Keibun Liu, Kensuke Nakamura, Takeshi Nishida, Hidenori Sumita, Shunsuke Taito, Shunsuke Takaki, Norihiko Tsuboi, Takeshi Unoki, Yasuyo Yoshino, Osamu Nishida
Institutions: Wakayama Medical University, Wakayama University, Kobe University, Kyoto Prefectural University of Medicine, Kakogawa Central City Hospital, Osaka Medical and Pharmaceutical University, St. Luke's International Hospital, Toyohashi SOZO University, Aso Iizuka Hospital, Fujita Health University Hospital, Juntendo University, Juntendo University Urayasu Hospital, The University of Queensland, Prince Charles Hospital, Yokohama City University, Osaka Prefectural Medical Center, Hiroshima University Hospital, National Center For Child Health and Development, Sapporo City University, Teine Keijinkai Hospital, Komazawa Women's University, Fujita Health University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,250
Awards: Interaction between GRK2 interactome and mitochondrial dysfunction for the development of chronic pain, Mitochondrial inflammation and its mechanisms in the pathogenesis of chronic pain., The effect of upper and lower limb neuromuscular electrical stimulation on muscle strength, metabolism, and long-term outcomes in ICU admitted patients., Development of a Comprehensive Database for Long-term Outcome Improvement in Critically Ill Patients
OpenAlex ID: W4392000913