Work

Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial

Year: 2024

Type: article

Abstract: Transcranial direct current stimulation (tDCS) has been used to noninvasively reduce epileptic activity in focal epilepsy. In this proof-of-principle N-of-1 trial in a patient with refractory focal epilepsy in left frontal lobe, we propose distributed constrained maximum intensity (D-CMI) for individually targeted and optimized multi-channel (mc-) tDCS [1] to reduce epileptic activity. Combined electro- and magnetoencephalography (EMEG) source analysis in a realistic calibrated head model [2] with modeled skull-burr holes (Fig.

Source: Brain stimulation

DOI: 10.1016/j.brs.2024.02.010

Authors: Marios Antonakakis, Fabian Kaiser, Stefan Rampp, Stjepana Kovac, Heinz Wiendl, Walter Stummer, Joachim Gross, Christoph Kellinghaus, Maryam Khaleghi-Ghadiri, Gabriel Möddel, Carsten H. Wolters

Institutions: University of Münster, Technical University of Crete, Hamburg Wasser (Germany), Universitätsklinikum Erlangen, University Hospital in Halle, University Hospital Münster, Klinikum Osnabrück

Language: English

Topic: Transcranial Magnetic Stimulation Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,020

Funders: European Commission, Deutscher Akademischer Austauschdienst, Deutsche Forschungsgemeinschaft, Bundesministerium für Gesundheit, Alexander S. Onassis Public Benefit Foundation, Medical Research Institute Sri Lanka, H2020 Marie Skłodowska-Curie Actions, German Academic Exchange Service

Awards: G3529185310, G376156729, G3977424416, Advancing brain research in children’s developmental neurocognitive disorders, G7821967040, G859850701, G8812548867

OpenAlex ID: W4392016305

FWCI: 1.045

Cites: 66

Cited by: 7

Related to: 10