Interim Effectiveness of Updated 2023–2024 (Monovalent XBB.1.5) COVID-19 Vaccines Against COVID-19–Associated Emergency Department and Urgent Care Encounters and Hospitalization Among Immunocompetent Adults Aged ≥18 Years — VISION and IVY Networks, September 2023–January 2024
Year: 2024
Type: article
Study design: Observational Study
Abstract: In September 2023, CDC's Advisory Committee on Immunization Practices recommended updated 2023-2024 (monovalent XBB.1.5)COVID-19 vaccination for all persons aged ≥6 months to prevent COVID-19, including severe disease.However, few estimates of updated vaccine effectiveness (VE) against medically attended illness are available.This analysis evaluated VE of an updated COVID-19 vaccine dose against COVID-19-associated emergency department (ED) or urgent care (UC) encounters and hospitalization among immunocompetent adults aged ≥18 years during September 2023-January 2024 using a test-negative, case-control design with data from two CDC VE networks.VE against COVID-19-associated ED/ UC encounters was 51% (95% CI = 47%-54%) during the first 7-59 days after an updated dose and 39% (95% CI = 33%-45%) during the 60-119 days after an updated dose.VE estimates against COVID-19-associated hospitalization from two CDC VE networks were 52% (95% CI = 47%-57%) and 43% (95% CI = 27%-56%), with a median interval from updated dose of 42 and 47 days, respectively.Updated COVID-19 vaccine provided increased protection against COVID-19associated ED/UC encounters and hospitalization among immunocompetent adults.These results support CDC recommendations for updated 2023-2024 COVID-19 vaccination.All persons aged ≥6 months should receive updated 2023-2024 COVID-19 vaccine.US Department of Health and Human Services | Centers for Disease Control and Prevention | MMWR | February 29, 2024 | Vol.73 | No. 8case-control design to estimate COVID-19 VE.Eligible patients must receive molecular testing (e.g., real-time reverse transcription-polymerase chain reaction [RT-PCR] testing) for SARS-CoV-2 during the 10 days preceding or up to 72 hours after a COVID-19-associated ED/UC encounter or hospital admission.**COVID-19 vaccination history is ascertained from state or jurisdictional registries, EHRs, and, in a subset of sites, medical claims data.IVY is a multisite, inpatient network including 26 hospitals in 20 U.S. states † † that uses a test-negative, case-control design to prospectively enroll patients with COVID-19-like illness (CLI) § § who receive testing for SARS-CoV-2 within 10 days ** COVID-19-like illness diagnoses were obtained from International Classification of Diseases, Tenth Revision (ICD-10) discharge codes.The specific codes used were COVID-19 pneumonia: J12.81 and J12.82; influenza pneumonia: J09.
Authors: Jennifer DeCuir, Amanda B. Payne, Wesley H. Self, Elizabeth A.K. Rowley, Kristin Dascomb, Malini B. DeSilva, Stephanie A. Irving, Shaun J. Grannis, Toan C. Ong, Nicola P. Klein, Zachary A. Weber, Sarah E. Reese, Sarah W. Ball, Michelle A. Barron, Allison L. Naleway, Brian E. Dixon, Inih Essien, Daniel Bride, Karthik Natarajan, Bruce Fireman, Ami B. Shah, Erica Okwuazi, Ryan Wiegand, Yuwei Zhu, Adam S. Lauring, Emily T. Martin, Manjusha Gaglani, Ithan D. Peltan, Samuel M. Brown, Adit A. Ginde, Nicholas M. Mohr, Kevin W. Gibbs, David N. Hager, Matthew Prekker, Amira Mohamed, Vasisht Srinivasan, Jay S. Steingrub, Akram Khan, Laurence W. Busse, Abhijit Duggal, Jennifer G. Wilson, Steven Y. Chang, Christopher Mallow, Jennie H. Kwon, Matthew C. Exline, Cristie Columbus, Ivana A. Vaughn, Basmah Safdar, Jarrod M. Mosier, Estelle S. Harris, Jonathan D. Casey, James D. Chappell, Carlos G. Grijalva, Sydney A. Swan, Cassandra Johnson, Nathaniel M. Lewis, Sascha Ellington, Katherine Adams, Mark W. Tenforde, Clinton R. Paden, Fatimah S. Dawood, Katherine E. Fleming-Dutra, Diya Surie, Ruth Link-Gelles, CDC COVID-19 Vaccine Effectiveness Collaborators, CDC COVID-19 Vaccine Effectiveness Collaborators, Shekhar Ghamande, Robert Gottlieb, Tresa McNeal, Catherine Raver, William Bender, Linda Fletcher, Phillip Heaton, Sheryl Kane, Charlene McEvoy, Sunita Thapa, Gabriela Vazquez-Benitez, Anne Frosch, Lois E Lamerato, Mayur Ramesh, Julie Arnofer, Harith Ali, Johns Hopkins, Bradley Crane, Padma Dandamudi, Kristin Goddard, John Hansen, Julius Timbol, Ousseny Zerbo, Katie Allen, Thomas Duszynski, William Fadel, Colin Rogerson, Nida Qadir, Catia Chavez, Bryant Doyle, David Mayer, Suchitra Rao, Carolina Rivas, Nicholas J. Johnson, Adrienne Baughman, Cara T. Lwin, Jillian P. Rhoads, Kelsey N. Womack, Margaret Dunne, Allison Ciesla, Josephine Mak, Morgan Najdowski, Caitlin Ray
Institutions: Intermountain Healthcare, Atrium Health Wake Forest Baptist, Barnes-Jewish Hospital, Beth Israel Deaconess Medical Center, Cleveland Clinic, Baystate Medical Center, Emory University, University of Utah, University of Michigan, Hennepin County Medical Center, Intermountain Medical Center, Yale University, Baylor Scott & White Medical Center - Temple, Kaiser Permanente Northern California, The Ohio State University, Vanderbilt University Medical Center, Stanford University, Baylor University Medical Center, Baystate Health
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: U.S. Department of Health and Human Services, U.S. Department of Veterans Affairs, Intermountain Healthcare, Eli Lilly and Company, Pfizer, Sanofi, Yale University, Kaiser Permanente, Vanderbilt University, University of Miami, Ohio State University, Emory University, Washington University in St. Louis, Cleveland Clinic, University of Washington, Johns Hopkins University, Hennepin County Medical Center, Intermountain Research and Medical Foundation, Regeneron Pharmaceuticals, Michigan Department of Health and Human Services, Vanderbilt University Medical Center, Kiniksa Pharmaceuticals, Seqirus, National Institutes of Health, Centers for Disease Control and Prevention, Goddard Space Flight Center, School of Medicine, Stanford University, University of California, Los Angeles, Wake Forest School of Medicine, School of Medicine, Indiana University, Irving Medical Center, Columbia University, Sanofi Pasteur, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, U.S. National Library of Medicine, National Center for Immunization and Respiratory Diseases, National Center for Advancing Translational Sciences, Janssen Pharmaceuticals, University of Colorado School of Medicine, Anschutz Medical Campus
OpenAlex ID: W4392297152