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Comparıson Of Serum Usp9x And Tgf-ß Levels In Chıldren Wıth Autısm Spectrum Dısorders Wıth Healthy Controls

Year: 2024
Type: article
Study design: Observational Study
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by a lack of social skills, verbal and nonverbal communication impairments, and limited and stereotypical interests and activities.Males are four times more likely than females to have it (1).Recent estimates from the Centers for Disease Control and Prevention (CDC) show that the prevalence of autism among American children has increased to one in 36, or around 2.8%, from one in 44 (2.3%) two years ago (2).Even though the etiology of autism is multifactorial, research points to a strong genetic component in the etiology of autism.Mutations or variations in certain genes involved in synaptic function and neuronal connectivity have been associated with an increased risk of developing autism (3).Recent studies suggest that protein cycling may play an important role in ASD (4).Protein homeostasis is a mechanism by which cells maintain physiological protein levels and abnormal neuronal homeostasis leads to abnormal protein levels and disorders associated with excessive protein aggregation.One of the main mechanisms of homeostasis is ubiquitylation, which is protein degradation by the ubiquitin-proteasome system; the other is the deubiquitylation system, which opposes this process by removing ubiquitin from proteins (5).Ubiquitylation is a posttranslational modification caused by the addition of ubiquitin, which consists of 76 amino acids, to the protein structure.In cells, the ubiquitin Introduction: USP9X has been associated with neurodevelopmental disorders due to its role in synaptic development and neural function.This study aimed to compare USP9X and TGF-β levels in children with autism and healthy controls, and explore their relationship with autism severity.Methods: Serum USP9X and TGF-β levels were measured in 41 healthy control children (aged 3-12 years) and 41 children with autism.Results: Our study revealed a significant increase in USP9X levels (p=0.001)among children with autism compared to controls.However, TGF-β levels showed no significant difference between the two groups.Furthermore, we observed a positive correlation between difficulty in making eye contact subscale and blood levels of both USP9X and TGF-β.Conclusions: This study is the first to compare serum USP9X levels in children with autism to healthy controls.Our findings suggest USP9X's potential role in autism development, emphasizing the need for further research on its involvement in neurodevelopmental processes.
DOI: 10.29399/npa.28650
Language: English
Open Access status: bronze
OpenAlex ID: W4392369697
FWCI:
Cites: 50
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Related to: 10