Work

Visible Light-Induced One-Pot Carbonylation of Alkyl Halides with Aryl Formates

Year: 2024

Type: article

Abstract: Described herein is the development of a visible-light-driven carbonylation of alkyl halides. The exploitation of visible light to activate Pd complexes and the use of formates to serve the dual role of a CO surrogate and a phenoxide source allow the preparation of esters in moderate to good yields. Its relatively mild reaction conditions and the ability to perform this transformation without direct handling of toxic CO gas provide a practical means to access esters from alkyl halides.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.3c02763

Authors: Padon Chuentragool, Aurapat Ngamnithiporn, Prachnawadee Hongboon, Somsak Ruchirawat

Institutions: Chulabhorn Research Institute, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Ministry of Higher Education, Science, Research and Innovation

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Research Council of Thailand, Thailand Science Research and Innovation