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Knee Buckling as an Atypical Adverse Effect of Clozapine: A Case Report

Year: 2024

Type: article

Abstract: Clozapine has become a widely popular and effective medication in the treatment of refractory schizophrenia and refractory bipolar disorder. Although the use of clozapine proves to be an effective resort, it has to be closely monitored due to its narrow therapeutic range and multiple dangerous adverse effects. In rare cases, clozapine has been known to cause an antagonistic myoclonic jerk that leads to knee buckling. Here, we present the case of a 29-year-old female who is being treated for schizoaffective disorder, bipolar, manic type, who reported two instances of knee buckling associated with falls while taking clozapine.

Source: Cureus

DOI: 10.7759/cureus.55865

Authors: Javeria Sahib Din, Ernesto Navarro Garcia, Hiba Al-Rubaye, Carlos Julian

Institutions: University of Central Florida, St. George's University, Kings County Hospital Center

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4392633745