[18]F-fluoroethyl-l-tyrosine positron emission tomography for radiotherapy target delineation: Results from a Radiation Oncology credentialing program
Year: 2024
Type: article
Abstract: Background and purpose The [18]F-fluoroethyl-L-tyrosine (FET) PET in Glioblastoma (FIG) study is an Australian prospective, multi-centre trial evaluating FET PET for newly diagnosed glioblastoma management. The Radiation Oncology credentialing program aimed to assess the feasibility in Radiation Oncologist (RO) derivation of standard-of-care (MR) and hybrid (MR + FET) target volumes, which incorporated pre-defined FET PET biological tumour volumes (BTVs). Materials and methods Central review and analysis of MR-derived target volumes (TV MR ) and hybrid target volumes (TV MR+FET ) was undertaken across three benchmarking cases. Associated BTVs were pre-defined by a sole nuclear medicine expert. Intraclass correlation coefficient (ICC) evaluated volume agreement. RO contour spatial and boundary agreement were evaluated (Dice similarity coefficient [DSC], Jaccard index [JAC], overlap volume [OV], Hausdorff distance [HD] and mean absolute surface distance [MASD]). Dose plan generation, involving one case per site, was also assessed. Results Data from 19 ROs across 10 trial sites (54 initial submissions, 8 resubmissions requested, 4 conditional passes) was assessed with an initial pass rate of 77.8 %, with all resubmissions passed. TV MR+FET were significantly larger than TV MR (p < 0.001) for all cases. Between ROs, volume agreement was moderate-to-excellent for GTV MR (ICC = 0.910; 95 % CI, 0.708–0.997) and good-to-excellent for GTV MR+FET (ICC = 0.965; 95 % CI, 0.871–0.999). Across all cases, GTV MR+FET showed greater spatial overlap and boundary agreement between ROs compared to GTV MR . CTV MR+FET showed lower average boundary agreement versus CTV MR (MASD: 1.73 mm vs. 1.61 mm, p = 0.042). All ten sites passed the planning case exercise. Conclusion The national FIG study credentialing program demonstrated feasibility in successful credentialing of 19 ROs across 10 study sites, resulting in increased expertise in TV MR+FET delineation.
Authors: Nathaniel Barry, Eng-Siew Koh, Martin A. Ebert, Alisha Moore, Roslyn J. Francis, Pejman Rowshanfarzad, Ghulam Mubashar Hassan, Sweet P. Ng, Michael Back, Benjamin Chua, Mark B. Pinkham, Andrew Pullar, Claire Phillips, Joseph Sia, Peter Gorayski, Hien Le, Suki Gill, Jeremy Croker, Nicholas Bucknell, Catherine Bettington, Farhan Syed, Kylie Jung, Joe Chang, Andrej Bece, Catherine Clark, Mori Wada, Olivia Cook, Angela Whitehead, Alana Rossi, Andrew Grose, Andrew M. Scott
Institutions: The University of Western Australia, UNSW Sydney, Sir Charles Gairdner Hospital, Trans Tasman Radiation Oncology Group, Austin Hospital, Austin Health, Royal North Shore Hospital, Royal Brisbane and Women's Hospital, Princess Alexandra Hospital, Peter MacCallum Cancer Centre, Royal Adelaide Hospital, Canberra Hospital, St George Hospital, The University of Melbourne, La Trobe University, Olivia Newton-John Cancer Research Institute
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,680
OpenAlex ID: W4392767775