Year: 2024
Type: article
Abstract: Background Although Shigella is an important cause of diarrhea in Kenyan children, robust research platforms capable of conducting incidence-based Shigella estimates and eventual Shigella-targeted clinical trials are needed to improve Shigella-related outcomes in children. Here, we describe characteristics of a disease surveillance platform whose goal is to support incidence and consequences of Shigella diarrhea as part of multicounty surveillance aimed at preparing sites and assembling expertise for future Shigella vaccine trials. Methods We mobilized our preexisting expertise in shigellosis, vaccinology, and diarrheal disease epidemiology, which we combined with our experience conducting population-based sampling, clinical trials with high (97%–98%) retention rates, and healthcare utilization surveys. We leveraged our established demographic surveillance system (DSS), our network of healthcare centers serving the DSS, and our laboratory facilities with staff experienced in performing microbiologic and molecular diagnostics to identify enteric infections. We joined these resources with an international network of sites with similar capabilities and infrastructure to form a cohesive scientific network, designated Enterics for Global Health (EFGH), with the aim of expanding and updating our knowledge of the epidemiology and adverse consequences of shigellosis and enriching local research and career development priorities. Conclusions Shigella surveillance data from this platform could help inform Shigella vaccine trials.
Source: Open Forum Infectious Diseases
DOI: 10.1093/ofid/ofad654
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,256
Awards: University of Virginia - to provide technical support to the EFGH shigella burden study and Global Pediatric Diarrhea Surveillance platform at WHO, that will improve our es..., University of Virginia - to provide technical support for molecular diagnostic approaches for shigella detection across multiple settings, University of Washington Foundation - to conduct a multi-center Shigella surveillance study to support the clinical development of vaccines against shigellosis, University of Washington Foundation - to support a multi-center Shigella surveillance study to support the clinical development of vaccines against shigellosis, G940555773
OpenAlex ID: W4393167136