Work

Metal ion release from orthodontic appliances: Concerns regarding potential carcinogenic effects

Year: 2024

Type: article

Abstract: • Metal Ion Release Concerns: Orthodontic appliances, such as brackets and wires, can release metal ions owing to corrosion processes, raising concerns about potential health risks. • Genotoxic Effects: In vitro studies have demonstrated the genotoxic effects of metal ions released from orthodontic appliances, particularly nickel and chromium, on human cells, suggesting potential carcinogenicity. • Clinical Evidence: Despite in vitro findings, clinical and epidemiological studies linking orthodontic treatment to cancer risk are inconclusive, with some studies failing to establish a significant association. • Regulatory Oversight: Regulatory agencies, including the FDA, have established guidelines for the biocompatibility and safety of orthodontic appliances. Manufacturers are required to conduct biocompatibility tests to ensure patient safety. • Future Directions: Further research is required to elucidate the long-term effects of metal ion release from orthodontic appliances on cancer risk. Quality control measures and regulatory oversight are essential to minimize the potential risks to patients undergoing orthodontic treatment.

Source: Oral Oncology Reports

DOI: 10.1016/j.oor.2024.100309

Authors: Hema Suryawanshi, Alka Hande, Arun Kumar Dasari, Kaladhar Reddy Aileni, Ibrahim AlZoubi, Santosh R. Patil

Institutions: Chhattisgarh Dental College & Research Institute, Datta Meghe Institute of Higher Education and Research, SVS Medical College, Jouf University

Language: English

Topic: Orthodontics and Dentofacial Orthopedics

Subfield: Orthodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,100