Association of Coagulation Dysfunction With Cardiac Injury in Hospitalized Patients With Covid-19
Year: 2024
Type: article
Study design: Observational Study
Abstract: Objective: To determine the association of coagulation dysfunction with cardiac injury in hospitalized patients with COVID-19. Study Design: Descriptive Cross Sectional. Place and Duration of Study: Department of Hematology, MTI-HayatabadMedical Complex, Peshawar, from Jun 2021 to Dec 2021. Methodology: A total of 103 patients hospitalized for COVID-19 were included in this study. The sample size was calculated by WHO Sample Size calculator with 7.20% proportion of cardiac injury in hospitalized COVID-19 patients, 5% margin of error and 5% significance level. Cardiac and coagulation biomarkers were recorded at the time of admission and later during hospitalization. To establish association between coagulation dysfunction and cardiac injury, spearman correlation coefficient was used. Results: Mean age of patients was 57.6+12.36 years. Mean d-dimer was 2.022+2.84 ug/mL, mean fibrin levels were 34.27+54.68 mg/dL and mean fibrinogen was 2.51+1.04 g/L, mean hsTn1 was 5.88+6.51 pg/mL, mean myohemoglobin was 65.49+52.2 ng/mL and mean CK-MB was 16.76+6.67 U/L. Cardiac injury was recorded in 23 (22.3%) patients hospitalized due to COVID-19. Conclusion: This study demonstrated a significant association of coagulation dysfunction with the development of cardiac injury as markers of coagulation function were found significantly synchronized with the dynamic progression of cardiac biomarkers.
Authors: Muizz Zahoor, Muhammad Shoaib, Saiqa Zahoor, Gul Rukh, Hafsa Tariq, Hamid Mahabat Khan
Institutions: Hayatabad Medical Complex, Pak International Medical College
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4393374907