Work

Renal upregulation of NCC counteracts empagliflozin-mediated NHE3 inhibition in normotensive but not in hypertensive male rat

Year: 2024

Type: article

Abstract: This study suggests that reduced NHE3-mediated sodium reabsorption in the renal proximal tubule may account, at least in part, for the BP-lowering effect of SGLT2 inhibitors in the setting of hypertension. It also demonstrates that chronic treatment with SGLT2 inhibitors upregulates NCC activity, phosphorylation, and expression in the distal tubule of normotensive but not hypertensive rats. SGLT2 inhibitor-mediated upregulation of NCC seems crucial to counteract proximal tubule natriuresis in subjects with normal BP.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00351.2023

Authors: Paulo C. Castro, Thiago M. Santos-Rios, Flavia L. Martins, Renato O. Crajoinas, Marcos V. Caetano, Lucília M. A. Lessa, Weverton M. Luchi, James A. McCormick, Adriana C. C. Girardi

Institutions: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Coração - HCFMUSP, Universidade Estadual do Ceará, Universidade Federal do Espírito Santo, Oregon Health & Science University

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Fundação de Amparo à Pesquisa do Estado de São Paulo, Ministério da Ciência, Tecnologia e Inovação, Conselho Nacional de Desenvolvimento Científico e Tecnológico, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Pleiotropic effects of antidiabetic agents and their pharmacological targets: renoprotective mechanisms beyond glycemic control, G2339903495, Molecular bases of renal tubular function and dysfunction, G505225972, Magnesium handling by the distal nephron, Regulation of renal ion transport by the CUL3-WNK-SPAK pathway, G984932397

OpenAlex ID: W4393389331

FWCI: 1.738

Cites: 60

Cited by: 16

Related to: 10