Work

Cryo-EM structures reveal two allosteric inhibition modes of PI3KαH1047R involving a re-shaping of the activation loop

Year: 2024

Type: article

Abstract: -driven cancers.

Source: Structure

DOI: 10.1016/j.str.2024.03.007

Authors: Xiuliang Huang, Kailiang Wang, Jing Han, Xiumei Chen, Zhenglin Wang, Tianlun Wu, Bo Yu, Feng Zhao, Xinjuan Wang, Huijuan Li, Zhi Xie, Xiaotian Zhu, Wenge Zhong, Xiaoming Ren

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $9,350

OpenAlex ID: W4393973776

FWCI: 1.957

Cites: 47

Cited by: 17

Related to: 10