Additional file 1 of Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysis
Year: 2022
Type: dataset
Abstract: Additional file 1: Table S1. Summary of GWAS data. Table S2. Single trait LDSC of LBD, AD, and PD GWAS. Table S3. Genome-wide significant SNPs (Pmtag < 5×10-8) of MTAG results of LBD and functional annotations. Association statistics of these SNPs from LBD GWAS and one-sided and two-sided ASSET analysis were also provided. Table S4. Genomic risk loci identified by FUMA using LBD GWAS. Table S5. Lead SNPs (P < 5×10-8 and r2 < 0.1) of LBD GWAS and MTAG results of LBD. Table S6. Summary of annotations of 2,160 validated SNPs. Table S7. GCTA-COJO analysis results. Table S8. 90% credible sets of 13 genomic risk loci. Table S9. PP4 of SNPs included in colocalization analysis. Table S10. Functional enrichment analysis using GARFIELD. Table S11. Gene-based analysis for MTAG results of LBD (after Bonferroni correction). Table S12. Transcriptome-wide association study using joint tissue imputation models and MTAG results of LBD (after Bonferroni correction in each tissue). Table S13. Candidate genes identified by both GCTA-fastBAT and TWAS. Table S14. Enrichment analysis for 40 candidate genes associated with LBD.
Source: Figshare
Institutions: Inner Mongolia University for Nationalities, Shandong University, Guangdong Pharmaceutical University, Zhejiang A & F University, Central South University, Guangxi University, Peking University, Huazhong Agricultural University, Shanghai University of Traditional Chinese Medicine, South China Botanical Garden, The Affiliated Yongchuan Hospital of Chongqing Medical University, National Center for AIDS/STD Control and Prevention,China CDC, Women's Hospital, School of Medicine, Zhejiang University, Jiangsu Province Hospital, First Affiliated Hospital Zhejiang University, Ocean University of China, Zhejiang University, Lanzhou University, Nanjing Medical University, Shandong Provincial Hospital, Air Force Medical University, Beijing Institute of Technology, Dalian Medical University, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Peking University First Hospital, China Academy of Chinese Medical Sciences, Beijing Children’s Hospital, Xi'an Jiaotong University
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4394385243