This work has been retracted.
RETRACTED ARTICLE: Therapeutic Effects of Panax notoginseng saponins in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation
Year: 2023
Type: dataset
Abstract: Panax notoginseng saponins (PNS) have been reported to have good anti-inflammatory effects. However, the anti-inflammatory effect mechanism in rheumatoid arthritis (RA) remains unknown. The focus of this research was to investigate the molecular mechanism of PNS in the treatment of RA. The primary active components of PNS were tested utilizing the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and Analysis Platform based on oral bioavailability and drug-likeness. The target databases for knee osteoarthritis were created using GeneCards and Online Mendelian Inheritance in Man (OMIM). The visual interactive network structure ‘active component – action target – illness’ was created using Cytoscape software. A protein interaction network was built, and associated protein interactions were analyzed using the STRING database. The key targets were analyzed using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) biological process enrichment analyses. The effects of PNS on cell growth were studied in human umbilical vein endothelial cells (HUVECs) treated with various doses of PNS, and the optimum concentration of PNS was identified. PNS was studied for its implication on angiogenesis and migration. The active components of PNS had 114 common targets, including cell metabolism and apoptosis, according to the network analysis. The therapeutic effects of the PNS components were suggested to be mediated through apoptotic and cytokine signaling pathways. In vitro, PNS therapy boosted HUVEC proliferation. Wound healing, Boyden chamber and tube formation tests suggested that PNS may increase HUVEC activity and capillary-like tube branching. This study clarified that for the treatment of RA, PNS has multisystem, multicomponent, and multitargeted properties.
Source: Figshare
Authors: Xinnan Ma, Xin Zhang, Yuanhang Kong, Bo Su, Leilei Wu, Daqian Liu, Xintao Wang
Institutions: Nanjing Agricultural University, Inner Mongolia Agricultural University, Beijing Tongren Hospital, Ministry of Education of the People's Republic of China, Shandong University of Traditional Chinese Medicine, Anhui Agricultural University, Shandong University, Harbin Medical University, Chongqing University, Guilin Medical University, Second Military Medical University, Yanbian University, Capital Medical University, Jilin University, Chinese Academy of Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Peking University, Beijing Normal University, National Health and Family Planning Commission, Zhengzhou University, Harbin University of Commerce, St Vincent's Hospital Sydney, Gansu University of Traditional Chinese Medicine, Third Affiliated Hospital of Harbin Medical University, Xinjiang Academy of Agricultural and Reclamation Science, Nanjing Drum Tower Hospital, National Center for Chronic and Noncommunicable Disease Control and Prevention, Shandong Provincial Hospital, First Affiliated Hospital of Xi'an Jiaotong University, Dongguan People’s Hospital, Zhongshan Hospital, Second Affiliated Hospital of Harbin Medical University, Renmin Hospital of Wuhan University, First Affiliated Hospital of Dalian Medical University, Biotechnology Research Institute, Jiangmen Central Hospital, Children's Hospital of Suzhou University, Ministry of Agriculture and Rural Affairs, Jiangsu Province Hospital, First Affiliated Hospital of Soochow University, Chinese People's Liberation Army, Shandong First Medical University, University of Chinese Academy of Sciences, Biotechnology Research Institute, China Agricultural University, Tianjin Medical University, Southern Medical University, Harbin Veterinary Research Institute, Nanjing Medical University, Nanjing University, Guangzhou Medical University, Tongji University, Bengbu Medical College, Zhongda Hospital Southeast University, Shanghai Pulmonary Hospital, Southeast University, Shanghai Sixth People's Hospital
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4394446509