Electronic supplementary material from “Synthesis of pyrimido[4,5-b]quinoline -4,6-diones and formylation: Ultrasonically assisted reactions”.
Year: 2024
Type: dataset
Abstract: Ultrasound-assisted synthesis of 5-aryl-tetrahydropyrimido[4,5-b]quinolindione derivatives 4 and 5 via a multicomponent reaction and subsequent formylation with Vilsmeier-Haack reagent were performed. Compounds were prepared by a one-pot method from 6-amino-3-methyl-2-(methylthio)pyrimidin-4(3H)-one or 6-amino-2-methoxy-3-methylpyrimidin-4(3H)-one, dimedone, and aromatic aldehydes through a Mannich-type reaction sequence, and then functionalized under ultrasound irradiation and Vilsmeier-Haack conditions to give β-chlorovinylaldehyde products. Ultrasonically assisted reactions, experimental simplicity, good yields without using metallic catalysts, and the control of hazardous material release are features of this simple procedure.
Source: Figshare
Authors: Trilleras, Jorge, Charris Molina, Andrés, Pérez-Gamboa, Alfredo, Acosta-Guzmán, Paola, Quiroga, Jairo
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4394459653