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Arterial stiffness in prehypertensive patients with white coat hypertension

Year: 2023
Type: article
Study design: Observational Study
Abstract: Introduction: White-coat hypertension (WCH) is associated with higher cardiovascular risk and increased all-cause mortality in the general population.The aim of this study was to determine whether there are differences in primary laboratory findings and pulse wave velocity (PWV) between prehypertensive patients with and without WCH. Materials and Methods:This study included healthy 62 patients (37 women, 25 men) with prehypertension without medication based on ambulatory blood pressure monitoring [ABPM]) from one family practice in Health center Zagreb-West.Patients were divided into two groups depending on having WCH (>20 mmHg difference from in office SBP from average ABPM SBP values).Basic laboratory, anthropometric, 24h ambulatory blood pressure, and pulse wave velocity (PWV) measurements were done in all patients.Mann-Whitney U test, Kruskal-Wallis's test and descriptive statistics were used in data processing in Statistica v.12.0.Results: WCH was found in 11 patients (17,7 %).Prehypertensive patients with WCH had significantly higher fasting glucose (median 5.7 [5.0-5.8]vs 5.3 [5.4-6.1]mmol/L;p < 0.001) and higher PWV (median 8.1 [7.1-8.8] vs. 9.0 [8.3-10.0]m/s; p=0.008).Patients with WCH had higher PWV in all three examined age groups (40-49 years p=0,074; 50-59 years p=0,003; 60-70 years p < 0,001).No differences were found in the concentration of potassium, LDL cholesterol, triglycerides, and body mass index (median 25.6kg/m2).Conclusion: This pilot study indicates the possible existence of accelerated atherosclerosis in prehypertensive individuals with WCH.It is necessary to conduct research on a larger sample to confirm these findings.
DOI: 10.21857/ypn4ocd1v9
Language: Croatian
Field: Medicine
Open Access status: hybrid
OpenAlex ID: W4394587281
FWCI:
Cites: 13
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Related to: 10