Work

A case report of hereditary leiomyomatosis and renal cell carcinoma (HLRCC)

Year: 2024

Type: article

Abstract: Leiomyomatosis and renal cell carcinoma (HLRCC) are rare autosomal dominant cancer syndromes characterized by cutaneous leiomyoma, uterine leiomyoma, and renal cell carcinoma (RCC). RCC in HLRCC is an aggressive metastatic tumor that develops at a young age. Here, we report the case of a patient with HLRCC who was diagnosed after the spontaneous rupture of a renal tumor. The patient underwent cytoreductive surgery, followed by combination therapy with the immune checkpoint inhibitor (ICI) nivolumab and cabozantinib, a tyrosine kinase inhibitor (TKI); however, no improvements were achieved.

Source: Urology Case Reports

DOI: 10.1016/j.eucr.2024.102738

Authors: Sunao Nohara, Shotaro Nakanishi, Tomoki Matsuo, Tomoko Tamaki, Seiici Saito

Institution: University of the Ryukyus

Language: English

Topic: Renal cell carcinoma treatment

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,060