Work

Dicarbonyl-modified low-density lipoproteins are key inducers of LOX-1 and NOX1 gene expression in cultured human umbilical vein endotheliocytes

Year: 2023

Type: article

Abstract: The expression of LOX-1 and NOX1 genes in human umbilical vein endotheliocytes (HUVECs) when cultured in the presence of low-density lipoproteins (LDL) modified with various natural dicarbonyls was investigated for the first time. It was found that of the investigated dicarbonyl-modified LDLs (malondialdehyde (MDA)-modified LDLs, glyoxal-modified LDLs, and methylglyoxal-modified LDLs), namely MDA-modified LDLs caused the greatest induction of LOX-1 and NOX1 genes, as well as genes of antioxidant enzymes and genes of signaling molecules in HUVECs. MDA-modified LDLs also induce the highest peroxiredoxins expression of the studied antioxidant enzyme genes. The key role of dicarbonyl-modified LDLs in the molecular mechanisms of vascular wall damage and endothelial dysfunction is discussed.

Source: Biochemistry (Moscow)

DOI: 10.31857/s0320972523120138

Authors: V. Z Lankin, M. G Sharapov, A. K Tihaze, R. G Goncharov, O. A Antonova, G. G Konovalova, V. I Novoselov

Institutions: Ministry of Health of the Russian Federation, National Medical Research Center of Cardiology, Russian Academy of Sciences, Institute of Cell Biophysics

Language: English

Topic: Nitric Oxide and Endothelin Effects

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4394749685

FWCI: 0.156

Cites: 54

Cited by: 1

Related to: 10