Synthesis and biological evaluation of 1,2,4-Triazolo[4,3-a][1,8] naphthyridines under Microwave condition
Year: 2024
Type: article
Abstract: Synthesis of 9-(4-bromophenyl)-6 aryl-[1,2,4]triazolo[4,3-a][1,8]naphthyridine-2-carbonitrile (4a-j) from 7-(2-(4bromobenzylidene)hydrazinyl)-6-aryl-1,8-naphthyridine-2-carbonitrile (3) oxidized with chloramines-T in methanol under microwave irradiation is a straight forward and very efficient process. Very high yields and excellent purities of the products were achieved. Elemental analysis, IR, 1H NMR, 13C NMR and Mass spectroscopy are used to characterize the produced compounds. All synthesized compounds were tested for their antimicrobial efficacy and found moderately active against different types of bacterial and fungal strains in comparison with Streptomycin, Nystatin. URN:NBN:sciencein.cbl.2024.v11.664
Source: Chemical Biology Letters
Authors: Kasaboina Kalyani Priya, Kumara Swamy Jella
Institution: Chaitanya
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4394926041