COVID-19 Vaccine Hesitancy: Umbrella Review of Systematic Reviews and Meta-Analysis
Year: 2024
Type: review
Study design: Systematic Review
Abstract: BACKGROUND: The unprecedented emergence of the COVID-19 pandemic necessitated the development and global distribution of vaccines, making the understanding of global vaccine acceptance and hesitancy crucial to overcoming barriers to vaccination and achieving widespread immunization. OBJECTIVE: This umbrella review synthesizes findings from systematic reviews and meta-analyses to provide insights into global perceptions on COVID-19 vaccine acceptance and hesitancy across diverse populations and regions. METHODS: We conducted a literature search across major databases to identify systematic reviews and meta-analysis that reported COVID-19 vaccine acceptance and hesitancy. The AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews) criteria were used to assess the methodological quality of included systematic reviews. Meta-analysis was performed using STATA 17 with a random effect model. The data synthesis is presented in a table format and via a narrative. RESULTS: = 97.59%). Higher acceptance rates were observed among health care workers and individuals with chronic diseases, at 64% (95% CI 0.57%-0.71%) and 69% (95% CI 0.61%-0.76%), respectively. However, lower acceptance was noted among pregnant women, at 48% (95% CI 0.42%-0.53%), and parents consenting for their children, at 61.29% (95% CI 0.56%-0.67%). The pooled vaccine hesitancy rate was 32% (95% CI 0.25%-0.39%) in the general population. The quality assessment revealed 19 high-quality, 38 moderate-quality, 15 low-quality, and 6 critically low-quality meta-analyses. CONCLUSIONS: This review revealed the presence of vaccine hesitancy globally, emphasizing the necessity for population-specific, culturally sensitive interventions and clear, credible information dissemination to foster vaccine acceptance. The observed disparities accentuate the need for continuous research to understand evolving vaccine perceptions and to address the unique concerns and needs of diverse populations, thereby aiding in the formulation of effective and inclusive vaccination strategies. TRIAL REGISTRATION: PROSPERO CRD42023468363; https://tinyurl.com/2p9kv9cr.
DOI: 10.2196/54769
Authors: Tahani Al Rahbeni, Prakasini Satapathy, Ramaiah Itumalla, Roy Rillera Marzo, Khalid A L Mugheed, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Ali A Rabaan, Hayam A Alrasheed, Maha F Al-Subaie, Nawal A Al Kaabil, Mohammed Alissa, Amani Ahmed A L Ibrahim, Hussain Abdulkhaliq Alsaif, Israa Habeeb Naser, Sarvesh Rustagi, Neelima Kukreti, Arkadiusz Dziedzic
Institutions: Riyadh Elm University, Saveetha University, The Apollo University, Curtin University Sarawak, Curtin University, Datta Meghe Institute of Higher Education and Research, Alfaisal University, Saudi Aramco Medical Services Organization, University of Haripur, Princess Nourah bint Abdulrahman University, Khalifa University of Science and Technology, Abu Dhabi Health Services, Prince Sattam Bin Abdulaziz University, Batterjee Medical College, Al-Mustaqbal University, Uttaranchal University, Graphic Era Hill University, Medical University of Silesia
Language: English
Subfield: Health
Field: Social Sciences
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $2,800
OpenAlex ID: W4396509404