Bridging the gap: evaluating high TB burden country data needs to support the potential introduction of TB vaccines for adolescents and adults: a workshop report
Year: 2024
Type: article
Abstract: High tuberculosis (TB) burden countries (HBCs) need to prepare for TB vaccine implementation alongside licensure, to ensure rapid rollout. WHO policy/implementation frameworks have been created to support this effort. Using WHO frameworks, we convened a workshop to ask HBC experts about what epidemiological, impact, feasibility and acceptability data they anticipated they would need to guide TB vaccine introduction. For required data, we asked HBC and global experts which data were already available, data collection planned, or gaps. HBC experts expressed high demand for epidemiological, impact, feasibility and acceptability data, reported variable availability of existing epidemiological data, and low availability for impact, feasibility, and acceptability data. Global experts reported additional knowledge of existing data on impact, upcoming collection of infection prevalence, acceptability and feasibility data, and potential epidemiological data collection on adolescents, adults, people living with HIV, and underweight individuals. HBC and global experts made key recommendations for: a coordinated data collation, collection, analysis and sharing system; updating existing HBC health and economic impact estimates and extending impact analyses to other HBCs; demand/market forecasting; resource gap mapping; aligning delivery strategies; addressing manufacturing, procurement, delivery, and regulatory barriers; sharing potential vaccine licensure timing; incorporating TB vaccine introduction strategies into NSPs, immunization programs, and health services; collecting vaccine hesitancy, mistrust, and misinformation data; collecting adolescent/adult vaccine demand generation data, and identifying funding. Experts recommended expanding this analysis to other areas of the WHO frameworks, including more HBC stakeholders, and repeating this analysis after country and community advocacy and socialization around different vaccine candidates.
Source: Frontiers in Tuberculosis
Authors: Rebecca A. Clark, Carly Young, Shaun Palmer, Erick Auma, Shelly Malhotra, Rupali Limaye, Birgitte Giersing, Lewis Schrager, Gerald Voss, Edine Tiemersma, Mike Frick, Ijeoma Edoka, Alemnew F. Dagnew, Thokozile Nkhoma, TB Vaccine Country Data Needs Group, Puck T. Pelzer, Richard G. White
Institutions: London School of Hygiene & Tropical Medicine, University of Cape Town, South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Stellenbosch University, International AIDS Vaccine Initiative, Johns Hopkins University, World Health Organization, TuBerculosis Vaccine Initiative, KNCV TB Plus, Treatment Action Group, University of the Witwatersrand
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,125
Funders: United States Agency for International Development, Bill and Melinda Gates Foundation, World Health Organization, Wellcome Trust, School of Public Health, University of Michigan, Public Health Foundation of India, University of Cape Town, Ministry of Health and Family Welfare, National Institutes of Health, Centers for Disease Control and Prevention, Medical Research Council, Economic and Social Research Council, National Institute of Allergy and Infectious Diseases
Awards: G1303243219, G1637947929, G2003503971, Improving scientific and public health decision making by developing technologies to increase use of robust methods to calibrate and analyse complex mathematical models, G2223609549, Infection prevention and control for drug-resistant tuberculosis in South Africa in the era of decentralised care: a whole systems approach, G242513792, G2660122252, Stichting Amsterdam Institute for Global Health and Development - to evaluate the extent to which Prevention of Mtb Infection is a surrogate for Prevention of TB Disease, Defining drivers of TB transmission in the era of universal ART, and implications for finding the walking well, G5697490169, London School of Hygiene and Tropical Medicine - to support optimal funding and implementation of tuberculosis interventions coordinated through the tuberculosis modelling consortium (TB-MAC)
OpenAlex ID: W4396566493