Pachira aquatica : biological activity and chemical composition of leaves, flowers, and seeds
Year: 2024
Type: article
Abstract: The chemical composition of Pachira aquatica crude extracts flowers, leaves, and seeds was obtained by UHPLC-ESI/qTOF and GC/MS. The antiproliferative activity was evaluated against the human tumour cell lines AGS (gastric), CaCo-2 (colorectal), MCF-7 (breast), and NCI-H460 (lung). The anti-inflammatory and cellular antioxidant activities were also studied. Flavonoids, phenolic acids, coumarins, and saturated fatty acids were identified in the samples. The concentration of extracts responsible for inhibiting 50% of nitric oxide production ranged from (149 to > 400 µg mL−1). Antiproliferative activity against the tumour cell lines was: AGS (GI50 175 to > 400 µg mL−1), Caco-2 (GI50 215 to > 400 µg mL−1), MCF7 (GI50 232 to > 400 µg mL−1) and NCI-H460 (GI50 208 to > 400 µg mL−1). Cellular antioxidant activity remained between 73% to > 2000%. The selectivity index (SI) ranged from 1.00 to 2.78, indicating low antiproliferative activity.
Source: Natural Product Research
Authors: Isabelle Luiz Rahal, Angelica Barbosa Dias, Gabriela Catuzo Canonico Silva, Marisa Cássia Vieira de Araújo Bento, Rhaira Fernanda Ayob Casalvara, José Eduardo Gonçalves, Nelson Barros Colauto, Giani Andrea Linde, Filipa Mandim, Josiana Vaz, Lillian Barros, Juliana Silveira do Valle, Zilda Cristiani Gazim
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4396802446