Work

Role of Reactive Oxygen Species in the Pathogenesis of Bronchial Asthma and Obstructive Pulmonary Diseases: Systematic Review

Year: 2024

Type: article

Abstract: The article discusses the role of reactive oxygen species (ROS) in the pathogenesis of bronchial asthma and obstructive pulmonary diseases. The review follows a structured approach beginning with a comprehensive search of electronic databases, then findings from the included studies were summarized and used to draw comprehensive conclusions. The authors state that increased activity of oxidative processes and insufficient activity of the antioxidant system lead to the accumulation of ROS in the respiratory tract. This leads to direct damage to epithelial cells, activation of inflammatory cells, and stimulation of inflammatory mediators. ROS also activate transcription factors that increase inflammation and airway obstruction. Thus, maintaining the balance of the oxidant-antioxidant system is an important strategy for the treatment of these diseases.Keywords: Reactive oxygen species; Bronchial asthma; Chronic obstructive pulmonary disease; Oxidative stress; Antioxidant system

Source: Advancements in Life Sciences

DOI: 10.62940/als.v11i2.2380

Authors: Imetkul Ismailov, Romanbek Kalmatov, Baktyiar Abdurakhmanov, Ali Munir Mirza, Jitendra Kumar Chaurasia

Institution: Osh State University

Language: English

Topic: Asthma and respiratory diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250