Work

Effects and cost-effectiveness of exercise vs. control activities on health-related quality of life in older persons with dementia: a randomized controlled trial

Year: 2024

Type: preprint

Abstract: Physical exercise may be a treatment option to improve health-related quality of life in persons with dementia. We determined the effects and cost-effectiveness of a 24-week walking and strength training intervention vs. a control intervention on proxy-reported health-related quality of life in persons with dementia. Ninety-one persons with dementia (82.3±7.0 years, 59 women, Mini Mental State Examination 20.2±4.4) were randomized. Health-related quality of life was assessed at baseline and after 24 weeks with EQ-5D-5L utility and EQ-VAS scores. We aimed to assess cost-effectiveness with a cost-utility analysis. We included literature-based no-activity reference values for comparison purposes. Fifty persons with dementia were analyzed. There were no significant effects of the exercise vs. control intervention or literature-based no activity reference values on health-related quality of life. A lack of exercise effects rendered cost-effectiveness analyses redundant. In the current sample, 24 weeks of walking and lower-limb strength training was not superior to control activities or literature-based no-activity reference values for health-related quality of life in persons with dementia.

DOI: 10.31234/osf.io/ctjg9

Authors: Lianne Maria Jantien Sanders, Tibor Hortobagyi, Ellen Scholten, Eddy van der Zee, Marieke van Heuvelen

Institutions: Lentis, University Medical Center Groningen, University of Groningen

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: Rijksuniversiteit Groningen, ZonMw, Universitair Medisch Centrum Groningen

Award: G5371188133