Work

PHYTOCHEMICALS, ANTIOXIDANT, AND ANTIDIABETIC ACTIVITIES OF ETHANOL EXTRACT OF Coleus atropurpureus Benth. LEAVES

Year: 2024

Type: article

Abstract: Coleus atropurpureus Benth leaves are traditionally used in Central Sulawesi, Indonesia to treat diabetes mellitus. This study aims to determine the secondary metabolite levels of the ethanol extract of C. atropurpureus leaves, its antioxidant activity, and its effect on blood glucose levels in Streptozotocin-induced diabetic rats. Extract phytochemical screening was carried out qualitatively according to standard methods. Quantitative analysis of flavonoids, saponins, tannins, and alkaloids by UV-Vis Spectrophotometry. The DPPH method was used to determine antioxidant activity. Diabetic rats were treated with ethanol extract of C. atropurpureus leaves at doses of 150, 200, and 250 mg/kg BW for 28 days, then their blood sugar levels were calculated. The ethanol extract of C. atropurpureus leaves showed antioxidant activity (IC50) 56.96 µg/mL. The 250 mg/kg BW dose group significantly reduced blood glucose levels. It can be concluded that the ethanol extract of C. atropurpureus leaves has the potential as a source of antidiabetic.

Source: RASAYAN Journal of Chemistry

DOI: 10.31788/rjc.2024.1728528

Authors: Joni Tandi, Agustinus Widodo, Rezky Yanuarty, Tien Wahyu Handayani, Maria Kanan

Institutions: Sekolah Tinggi Ilmu Farmasi Pelita Mas Palu, Tadulako University, Universitas Tompotika Luwuk

Language: English

Topic: Natural Antidiabetic Agents Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Universitas Tadulako