Synthesis of 1,2′‐Spirobi[indene]‐1,3‐diones by Pd(II)‐Catalyzed C−H Activation and Alkynes Annulation Reaction
Year: 2024
Type: article
Abstract: An intermolecular annulation reaction of 2‐aryl‐1,3‐indandions with alkynes was reported using Pd(OAc)2 to access spirobi[indene]‐1,3‐diones. Under palladium catalysis, the substrates form a homocoupling dimer intermediate through a catalytic dehydrogenative cross‐coupling process. The palladium(II) species could come from dimer or 2‐aryl‐1,3‐indandion. Notably, this pathway is not typically observed in enol‐directed formal sp3 C−H functionalization/oxidative annulation palladium chemistry. This transformation provides a route to access a class of functionalized spiro carbocyclic indenes.
Source: Advanced Synthesis & Catalysis
Institution: Nanyang Normal University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Award: G7859783552
OpenAlex ID: W4396935643