Evaluation of the Ex vivo and In vitro Antidiabetic and Antioxidant Activities of the Hydroalcoholic Extract of Psidium guajava L. Leaves (Myrtaceae)
Year: 2024
Type: article
Abstract: Objective: Antidiabetic activity was assessed by the skeletal muscle glucose uptake test and antioxidant potential by the total antioxidant capacity, reducing power and DPPH test. Materials and Methods: Same-sex Sprague Dawley rats weighing 150±20 g and approximately 3 months old and different concentrations of the extract obtained from 500 g of P. guajava leaves powder were used for the following methods: reduction, free radical scavenging, glucose uptake by skeletal muscle. Results: In terms of antioxidant potential, the extract showed significant activity in a dose-dependent manner. In addition, the extract potentiated glucose uptake in the presence and absence of insulin. Compared with metformin and glibenclamide, the extract increased glucose uptake to a greater extent. Conclusion: This study shows that the hydroethanolic extract of guava leaves is one of the best recipes for helping to delay the complications associated with diabetes.
Source: Asian Journal of Biology
Institution: University of Lomé
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4398205802