Work

Clozapine abrupt cessation fueling overlap neuroleptic malignant syndrome and serotonin syndrome with oculomotor dysfunction: a case report

Year: 2024

Type: article

Abstract: Neuroleptic Malignant Syndrome (NMS) and Serotonin Syndrome (SS) are life-threatening conditions caused by adverse reactions to neuroleptics and antidepressant medications. The overlap of both syndromes is rare but has been described previously. Differentiating between both entities based on the clinical presentation can be difficult. We present a case of a young male patient with history of schizophrenia, admitted to the Medical Intensive Care Unit (MICU) for septic shock, who developed NMS and SS with oculomotor dysfunction following the abrupt cessation of clozapine while still being on an antidepressant.

Source: Brain Disorders

DOI: 10.1016/j.dscb.2024.100141

Authors: Khaled Zammar, Majd A․AbuAlrob, Ahmad Meer, Boulenouar Mesraoua, Abeer Safan

Institutions: Hamad General Hospital, Hamad Medical Corporation, Weill Cornell Medical College in Qatar

Language: English

Topic: Electroconvulsive Therapy Studies

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,700