Work

Systemic treatment of mismatch repair deficient/microsatellite instability-high metastatic colorectal cancer—single versus double checkpoint inhibition

Year: 2024

Type: editorial

Abstract: Microsatellite instability (MSI) is found in ∼5% of all patients with metastatic colorectal cancer (mCRC). Solid evidence has shown that MSI-high/mismatch repair deficient (MSI-H/dMMR) tumors are less responsive to chemotherapy and sensitive to immunotherapy due to a higher tumor neoantigen load and immune cell infiltration.1,2

Source: ESMO Open

DOI: 10.1016/j.esmoop.2024.103483

Authors: D. Marinelli, A. Sabatini, E. Bengala, F. Ciurluini, V. Picone, D. Santini, F. Pietrantonio, D. Rossini, C. Cremolini

Institutions: Sapienza University of Rome, Policlinico Umberto I, Fondazione IRCCS Istituto Nazionale dei Tumori, University of Florence, University of Pisa, Azienda Ospedaliera Universitaria Pisana

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,730

OpenAlex ID: W4399301830

Cites: 13

Cited by: 4

Related to: 10