Bushy‐Tailed QACs: The Development of Multicationic Quaternary Ammonium Compounds with a High Degree of Alkyl Chain Substitution
Year: 2024
Type: article
Abstract: Quaternary ammonium compounds have served as a first line of protection for human health as surface disinfectants and sanitizers for nearly a century. However, increasing levels of bacterial resistance have spurred the development of novel QAC architectures. In light of the observed reduction in eukaryotic cell toxicity when the alkyl chains on QACs are shorter in nature (≤10 C), we prepared 47 QAC architectures that bear multiple short alkyl chains appended to up to three cationic groups, thus rendering them "bushy-tailed" multiQACs. Antibacterial activity was strong (often ~1-4 μM) in a varied set of bushy-tailed architectures, though observed therapeutic indices were not significantly improved over QAC structures bearing fewer and longer alkyl chains.
Source: ChemMedChem
Authors: Zachary E. A. Toles, Laura M. Thierer, Alice Wu, Elise L. Bezold, Diana Rachii, Christian A. Sanchez, Germán G. Vargas‐Cuebas, Taylor M. Keller, Patrick J. Carroll, William M. Wuest, Kevin P. C. Minbiole
Institutions: Villanova University, Emory University, University of Pennsylvania
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: MRI: Acquisition of a Liquid Chromatography Tandem Mass Spectrometer to Enhance Undergraduate Research and Teaching at a Primarily Undergraduate Institution, G1627413954, G1927708617, Investigating the impact of collagenase in Clostridioides difficile pathogenesis, MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Enhance Undergraduate Research and Teaching at a Primarily Undergraduate Institution, The Development of Novel Disinfectants to Overcome Bacterial Resistance, Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific Inhibitors, Graduate Training in the Pharmacological Sciences
OpenAlex ID: W4399708697