Year: 2024
Type: article
Abstract: Circulating cell-free DNA (cfDNA) constitutes a fragment of DNA released into the blood through cellular apoptosis or necrosis.In human medicine, cfDNA has been studied as a disease severity biomarker.Recent studies have shown that concentrations of cfDNA in dogs with immune-mediated and tumor-related diseases are increased.Pancreatitis is known to be caused by excessive release of trypsin, which leads to edema, inflammation, necrosis, and apoptosis in the pancreas.Based on the results of research showing an increase of cfDNA due to apoptosis and necrosis of cells, we hypothesized that cfDNA concentration would increase in the presence of pancreatitis.A total of 35 dogs were studied, including 21 with pancreatitis and 14 without any inflammatory diseases (normal group).The results showed that the concentration of cfDNA in dogs with pancreatitis was approximately twice that of normal dogs (median 0.0912 ng/μL.p-value 0.028).This result suggests that cfDNA can serve as a new biomarker for estimating pancreatitis severity.
Source: Journal of Veterinary Clinics
Authors: Jae-Hun Kim, Soo-Yeon Jeong, Chul Park
Institutions: Jeonbuk National University, Kyung-in Women's University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G198860292, G2929109316
OpenAlex ID: W4400220128