Get started
Work

Synthesis and Investigation of Biological Activity of New Betulonic Acid Derivatives Containing 1,2,3-Triazole Fragments

Year: 2024
Type: article
Abstract: The results of this study showed that the compounds synthesized by the authors have significant potential due to their antibacterial and cytotoxic properties. The apparent antibacterial activity demonstrated by the compounds suggests that they are active antimicrobial agents against common microbial pathogens that cause various socially significant infectious diseases. Compound 6 showed pronounced antimicrobial activity against the Gram-positive test strain Staphylococcus aureus ATCC 6538, and compound 7 demonstrated pronounced antimicrobial activity against the Gram-negative test strain Escherichia coli ATCC 25922 (MIC = 6.3 µg/mL). This allowed us to consider these compounds to have great potential.
Source: Molecules
DOI: 10.3390/molecules29133149
Authors: Roza I. Jalmakhanbetova, Gulim K. Mukusheva, Alisher Sh. Abdugalimov, Zharkyn Zh. Zhumagalieva, Wim Dehaen, Stijn Anthonissen, Yerlan M. Suleimen, Roza B. Seidakhmetova
Institutions: L. N. Gumilyov Eurasian National University, Karaganda Buketov University, Astana International University, KU Leuven, Kazakh Technology and Business University named after K.Kulazhanov, Karaganda Medical University
Language: English
Field: Chemistry
Open Access status: gold
Estimated APC paid: $3,069
OpenAlex ID: W4400242567
FWCI: 0.687
Cites: 65
Cited by: 5
Related to: 10