The impact of preservation solutions for static cold storage on kidney transplantation outcomes: Results of a Brazilian nationwide multicenter study
Year: 2024
Type: article
Study design: Observational Study
Abstract: This study evaluated the current practices of selecting cold storage preservation solutions in Brazil and their impact on delayed graft function (DGF) incidence and 1-year outcomes in kidney transplant recipients. A retrospective cohort study was conducted, including 3,134 brain-dead deceased donor kidney transplants performed between 2014 and 2015 in 18 Brazilian centers. The most commonly used preservation solution was Euro-collins (EC, 55.4%), followed by Histidine-tryptophan-ketoglutarate (HTK, 30%) and Institut Georges Lopez (IGL-1, 14.6%). The incidence of DGF was 54.4%, with 11.7% of patients requiring dialysis for more than 14 days, indicating prolonged DGF. Upon adjusting for confounding variables, HTK demonstrated a significantly lower risk of DGF than EC (OR 0.7350.82500.926), as did IGL-1 (OR 0.6050.7120.837). Similar protective effects were observed for prolonged DGF when comparing HTK (OR 0.4780.5990.749) and IGL-1 (OR 0.4780.6810.749) against EC. No significant association was found between preservation solutions and 1-year death-censored graft survival. In conclusion, EC was the most frequently used cold storage perfusion solution, demonstrating a higher incidence and duration of DGF compared with HTK and IGL-1, but with no impact on 1-year graft survival.
Source: PLoS ONE
Authors: Tainá Veras de Sandes-Freitas, Lucio Requião Moura, Deise Rosa de Boni Monteiro de Carvalho, Valter Duro Garcia, Luis Gustavo Modelli de Andrade, Marilda Mazzali, Roberto Ceratti Manfro, Luciane Mônica Deboni, Elias Davi-Neto, Claudia Maria Costa de Oliveira, Frederico Castelo Branco Cavalcanti, Rafael Lage Madeira, Ronaldo de Matos Esmeraldo, Denise Rodrigues Simão, Ana Carolina Guedes Meira, Gustavo Fernandes Ferreira, Marcus Lasmar, Alexandre Tortoza Bignelli, Alvaro Pacheco-Silva, José Medina Pestana, Hélio Tedesco Silva, on behalf of the DGF-Brazil Study Group
Institutions: Universidade Federal do Ceará, Hospital Universitário Walter Cantídio, Hospital Geral de Fortaleza, Hospital do Rim e Hipertensão, Universidade Federal de São Paulo, Universidade Estadual Paulista (Unesp), Universidade Estadual de Campinas (UNICAMP), Hospital de Clínicas de Porto Alegre, Hospital Municipal São José, Universidade de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Real Hospital Português, Hospital Felício Rocho, Santa Casa de Montes Claros - Irmandade Nossa Senhora das Mercês, Hospital Universitário Cajuru, Hospital Israelita Albert Einstein
Language: English
Subfield: Transplantation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,290
OpenAlex ID: W4400350367