Skin permeation studies using new nanoformulations containing cannabidiol for therapeutic purposes
Year: 2024
Type: article
Abstract: A possible route of cannabinoid administration is the topical-transdermal route.In this research, a chromatographic method to identify cannabidiol was developed, studies were also carried out using Franz cells and Confocal Raman Spectroscopy with two unprecedented nanoformulations (TRANS and CLN TRANS) containing cannabidiol (CBD).The CLN TRANS formulation presented a greater amount of CBD in the stratum corneum (SC) of the skin than TRANS.However, in the epidermis and dermis the result was the opposite.The peak intensities in Raman spectroscopy showed an equal amount of CBD in the dermis of the skin with both formulations until 4 hours of application, but the intensity of CBD decreased on the skin where CLN TRANS was applied after 8 hours.Therefore, the TRANS formulation continued to penetrate the human skin to deliver CBD deeper than CLN TRANS, showing promising results as a candidate for pain relief in patients.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
Award: G6138145098
OpenAlex ID: W4400445940