Synthesis and Properties of 1,1'-(hexane-1,6-diyl)bis[3-(3-hydroxymethyl)-5,7-r,r-methyladamantan-1-yl]urea as Potential Inhibitors of Soluble Epoxide Hydrolase Seh
Year: 2024
Type: article
Abstract: Reaction of 1,6-hexamethyldiisocyanate with (3-amino-5,7-R,R-1-adamantile)With methanol, symmetrical 1,1'-(hexane-1,6-diyl)bis[3-(3-hydroxymethyl)-5,7-R,R-methyladamantan-1-yl]urea was obtained with a yield of 74-93 %. The reaction proceeds regioselectively along the amino group of the substrate. The molecular coupling of inhibitors with soluble epoxy hydrolase sEH was carried out and differences in the mechanism of inhibitor binding from the presence of a hydroxymethyl group and the number of methyl groups in the adamantile substituent were established.
Authors: V.S. DYACHENKO, B.P. GLADKIKH, D.V. DANILOV, E.S. ILYINA, G.M. BUTOV
Institution: Volgograd State Technical University
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4401035629