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Phytochemical Profiling, Antioxidant and Antimicrobial Potentials of Ethanol and Ethyl Acetate Extracts of Chamaenerion latifolium L.

Year: 2024
Type: article
Abstract: The study investigates the phytochemical profile, antioxidant capacity, and antimicrobial activities of ethanol (ChL-EtOH) and ethyl acetate (ChL-EtOAc) extracts from Chamaenerion latifolium L. (ChL) harvested in Kazakhstan. The ChL-EtOH extract exhibited higher total phenolic (267.48 ± 3.44 mg GAE/g DE) and flavonoid content (24.18 ± 1.06 mg QE/g DE) compared to ChL-EtOAc. HPLC-UV-ESI/MS identified key phenolic acids and flavonoids, including gallic acid, chlorogenic acid, and quercetin 3-glucoside. FT-IR analysis confirmed the presence of characteristic functional groups. Antioxidant assays revealed strong DPPH scavenging and FRAP activities, with ChL-EtOH showing superior results (IC50 = 21.31 ± 0.65 μg/mL and 18.13 ± 0.15 μg/mL, respectively). Additionally, ChL-EtOH displayed notable antimicrobial efficacy against Gram-positive and Gram-negative bacteria, as well as the fungal strain Candida albicans. These findings suggest that ethanol extraction is more efficient for isolating bioactive compounds from ChL, underscoring its potential for pharmaceutical and nutraceutical applications.
DOI: 10.3390/ph17080996
Authors: Akmaral Kozhantayeva, Nurgul Tursynova, Ainagul Kolpek, Yelaman Aibuldinov, Arailym Tursynova, Togzhan Mashan, Zhazira Mukazhanova, Manshuk Ibrayeva, Aizhan Zeinuldina, Aisha Nurlybayeva, Zhanar Iskakova, Yerbolat Tashenov
Institutions: L. N. Gumilyov Eurasian National University, Sarsen Amanzholov East Kazakhstan University, Caspian University, Astana Medical University, M. Kh Dulati Taraz State University, Dulaty University
Language: English
Subfield: Plant Science
Open Access status: gold
Estimated APC paid: $3,296
OpenAlex ID: W4401209019
FWCI: 7.393
Cites: 81
Cited by: 35
Related to: 10