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Hydrophilic extract of Pistacia vera pericarp protects against phenylhydrazine-induced hepatotoxicity and hemolytic anemia.

Year: 2024
Type: article
Abstract: Objective: pericarp extract (PVPE) in a rat model of phenylhydrazine (PHZ)-induced anemia. Materials and Methods: PVPE was prepared using the maceration method. The extract was administered at doses of 20, 80, and 160 mg/kg for 28 days to normal and PHZ-treated rats. The effects of PVPE were evaluated in terms of changes in biochemical, histological, hematological, and molecular biomarkers in the liver and blood. Results: Administration of PVPE to the anemic animals significantly restored these deleterious effects on hematological parameters compared to the anemic group. Kupffer cell activation was seen in the liver tissue of the anemic rats. Administration of PVPE mitigated these deleterious effects. Conclusion: PVPE has potent antioxidant activity and may represent a promising treatment for anemia and liver protection in clinical settings.
DOI: 10.22038/ajp.2024.23925
Authors: Fatemeh Amin, Najmeh Parvaz, Nahid Askari, Morteza Khademalhosseini, Sakineh Khanamani Falahatipour, Iman Fatemi, Fatemeh Khajehasani, Zahra Taghipour, Soudeh Khanamani Falahati-Pour
Language: English
Subfield: Pharmacology
Open Access status: green
OpenAlex ID: W4401237456
FWCI: 1.184
Cites: 35
Cited by: 5
Related to: 10