Multiple Intracranial Germinomas: A Case Report
Year: 2024
Type: article
Study design: Case Report
Abstract: Germinomas are malignant tumors derived from primitive germ cells located in the midline structures of the brain, namely the pineal and/or sellar region. We report a case of multiple localization of germinoma in a 21-year-old patient with moderate headache of progressive onset; complicated by bilateral ptosis, right hyperacusis and swallowing and walking disorders. Brain MRI showed multiple diffuse nodular lesions above and below the tentorial level. Tumor markers screened in the blood were negative. The patient underwent an endoscopic biopsy and a ventriculoperitoneal shunt. Anatomopathological and immunohistochemical examination confirmed the diagnosis of germinoma. The postoperative evolution was favorable and the patient was scheduled for adjuvant treatment with chemotherapy and radiotherapy. Metastatic germinomas are sensitive to radiotherapy and chemotherapy. The surgical approach is mainly used for histological diagnosis.
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4401285385