Design, synthesis and evaluation of novel norfloxacin analogs as potent anticancer and antioxidant agents
Year: 2024
Type: article
Abstract: Aim: To synthesize a novel series of norfloxacin analogs and to evaluate biological activity.Methodology: Novel norfloxacin analogs were synthesized and characterized by NMR and mass spectrometry. Antiproliferative and antioxidant properties were studied.Results: Compound 2f was the most potent against HeLa cell-line with 100% inhibition of cell viability IC50 = 3.1 ± 0.2 μM. All compounds exhibit moderate to excellent antioxidant properties. Docking study demonstrates higher binding affinity of compounds with respective anticancer (B-cell lymphoma-2) and (tyrosinase) antioxidant targets. In silico absorption, distribution, metabolism and excretion profile of compounds proves all synthesized compounds follow Lipinski’s rule of drug likeness, non toxic and possess passive gastrointestinal absorption.Conclusion: The biological profile suggest that the synthesized norfloxacin analogs can be a novel scaffold for future anticancer drug development.
Source: Future Medicinal Chemistry
Institutions: COMSATS University Islamabad, People's University of Medical and Health Sciences for Women, Inserm, Normandie Université, Centre François Baclesse, Cancers et Préventions, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers, Université de Caen Normandie, National Institute for Biotechnology and Genetic Engineering, Pakistan Institute of Engineering and Applied Sciences
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funder: University of Karachi
OpenAlex ID: W4401428193