Determination of Swelling Kinetics and Diffusion Mechanisms of Chemically Crosslinked Porous Chitosan Hydrogels
Year: 2024
Type: article
Abstract: Chitosan hydrogels have gained popularity in a variety of industrial applications due to their biocompatibility, biodegradability, and varied physicochemical features. Understanding these hydrogels' swelling dynamics and diffusion processes is crucial for improving their efficacy in drug delivery, tissue engineering, and wound healing. This work aims to examine the processes of swelling and diffusion in chemically crosslinked porous chitosan hydrogels. The swelling kinetics of the hydrogels were investigated using Fick's diffusion mathematical model to determine the effects of different molecular weights of chitosan on the swelling behavior at pH: 2.0, pH: 5.6 and pH: 7.4. Chitosan hydrogels cross-linked with glutaraldeyhde showed Super Case II Diffusion according to Fick's laws of diffusion.
Source: Open Journal of Nano
DOI: 10.56171/ojn.1488770
Institution: Yalova University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4401430571